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BI-9627 (hydrochloride)

BI-9627 (hydrochloride)

Item no.	HY-18071A-25mg
Manufacturer	MedChem Express
CASRN	1422252-46-7
Amount	25 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	98.01
Formula	C16H20ClF3N4O2
Citations	[1]Huber JD, et al. Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat. J Med Chem. 2012;55(16):7114-7140.
Smiles	NC(NC(C1=CC=C(C2CCN(C(C)=O)CC2)C(C(F)(F)F)=C1)=O)=N.Cl
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	392.80
Clinical Information	No Development Reported
Manufacturers Research Area	Cardiovascular Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)
Target	Na+/H+ Exchanger (NHE)
Manufacturers Target	Na+/H+ Exchanger (NHE)
Manufacturers Pathway	Membrane Transporter/Ion Channel
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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