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Folinic acid

Folinic acid

Item no.	HY-17556-5mg
Manufacturer	MedChem Express
CASRN	58-05-9
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.90
Formula	C20H23N7O7
Citations	Appl Microbiol Biotechnol. 2024 Dec;108(1):1-15.<br>bioRxiv. 2023 Feb 28.<br>JAMA Oncol. 2022 Jan 1;8(1):e215445.<br>Mol Oncol. 2020 Nov;14(11):2894-2919.<br>NPJ Precis Oncol. 2023 Dec 8;7(1):128.<br>Virology. 2023 Jun 21.<br>EBioMedicine. 2024 Mar 13:102:105041.<br>J Mol Med (Berl). 2019 Aug;97(8):1183-1193.<br>Nat Commun. 2020 Apr 14;11(1):1792.<br>J Mol Med (Berl). 2019 Aug;97(8):1183-1193.<br>[1]Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.<br>[2]Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.
Smiles	O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2N(C=O)C3=C(N=C(N)NC3=O)NC2)C=C1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	leucovorin
Similar products	58-05-9
Available
Product Description	Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity[1].
StorageTemperature	-20°C (Powder, protect from light, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	473.44
Clinical_Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : 250 mg/mL (ultrasonic)
Manufacturers Target	Antifolate; Endogenous Metabolite
Isoform	Human Endogenous Metabolite
Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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