TCIP 1

Item no.	HY-156531-25mg
Manufacturer	MedChem Express
CASRN	3005886-78-9
Amount	25 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.01
Formula	C50H58Cl2N12O6S
Citations	[1]Gourisankar S, et al. Rewiring cancer drivers to activate apoptosis. Nature. 2023 Jul 26.
Smiles	O=C(C1CCN(C2=NC=C(Cl)C(NC3=CC4=C(N(C)C(C(OCC(NC)=O)=C4)=O)C(OC)=C3)=N2)CC1)NCCCCCCCNC(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	JWZ-7-7
Available
Product Description	TCIP 1 is a transcriptional/epigenetic CIPs (TCIP) small molecule consisting of covalent links to small molecules capable of binding to BCL6 and capable of binding to BRD4, respectively. TCIPs aids cell death gene expression by recruiting endogenous cancer drivers or downstream transcription factors to the promoters of cell death genes. TCIP 1 also plays a gain-of-function mechanism with shows cell specificity and tissue specificity. TCIP 1 forms a gain-of-function ternary complex with BCL6 and BRD4, Inhibits the blocking effect of BCL6 on apoptosis gene, and generates transcriptional extension of pro-apoptotic genes, thus activates apoptosis. TCIP 1 also significantly inhibits the expression of the oncogene MYC and inhibits the growth of diffuse large B-cell lymphoma (DLBCL)[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
MolecularWeight	1026.04
Clinical_Information	No Development Reported
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturers Applications	Cancer-programmed cell death
Pathway	Epigenetics; Immunology/Inflammation
Manufacturers Product type	Reference compound

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Amount: 25 mg

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