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Tyrphostin 23

Tyrphostin 23

Item no.	HY-15644-5mg
Manufacturer	MedChem Express
CASRN	118409-57-7
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.43
Formula	C10H6N2O2
Citations	[1]Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52.<br>[2]Nanzer AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004 Aug;151(2):233-40.<br>[3]Hohnholt MC, et al. The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23. Neurochem Int. 2017 Jan;102:13-21.
Smiles	N#C/C(C#N)=C/C1=CC=C(O)C(O)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Tyrphostin A23; RG-50810; AG 18
Available
Product Description	Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	186.17
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Isoform	EGFR/ErbB1/HER1
Pathway	JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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