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PI3Kδ-IN-14

PI3Kδ-IN-14

Item no.	HY-155975-1ea
Manufacturer	MedChem Express
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C26H20ClFN8O
Citations	[1]Tang Y, et al. Discovery of Highly Selective and Orally Bioavailable PI3K未 Inhibitors with Anti-Inflammatory Activity for Treatment of Acute Lung Injury. J Med Chem. 2023 Aug 22.
Smiles	ClC1=CC=C2C(N(N=C2[C@@H](N3C4=C(C(C5=CC(F)=C(C=C5)OC)=N3)C(N)=NC=N4)C)C6=CC=CN=C6)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	PI3Kδ-IN-14 (Compound (S)-29) is a selective PI3Kδ inhibitor (IC50: 0.8 nM, Kd: 84.8 nM). PI3Kδ-IN-14 binds to the ATP-binding site of the kinase domain of PI3Kδ. PI3Kδ-IN-14 has anti-inflammatory activity by inhibiting the PI3K/AKT pathway. PI3Kδ-IN-14 ameliorates acute lung injury (ALI)[1].
Shipping	Room temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	514.94
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Target	PI3K
Manufacturers Target	PI3K
Manufacturers Pathway	PI3K/Akt/mTOR
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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