Item no. |
HY-15477-5mg |
Manufacturer |
MedChem Express
|
CASRN |
132836-42-1 |
Amount |
5 mg |
Quantity options |
10mM/1mL
10 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.92 |
Formula |
C20H20BrNO2 |
Citations |
[1]Sun JJ, Kim HJ, Seo HG, et al. YS49,1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. Life Sci. 2008;82(11-12):600-7.<br/>[2]Kang YJ, et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999 Sep;128(2):357-64.<br/>[3]Hsu YH, et al. RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. J Cell Physiol. 2014 Oct;229(10):1455-65. |
Smiles |
OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.[H]Br |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Available |
|
Product Description |
YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors[1][2][3]. |
StorageTemperature |
4°C (Powder, stored under nitrogen) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
386.28 |
Clinical Information |
No Development Reported |
Manufacturers Research Area |
Cardiovascular Disease; Endocrinology |
Solubility |
DMSO : 100 mg/mL (ultrasonic)|H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C) |
Target |
Adrenergic Receptor; Akt; Angiotensin Receptor; PI3K |
Manufacturers Target |
Adrenergic Receptor; Akt; Angiotensin Receptor; PI3K |
Manufacturers Pathway |
GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.