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Copanlisib (dihydrochloride)

Copanlisib (dihydrochloride)

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Item no.	HY-15346A-5mg
Targets	PI3K
CASRN	1402152-13-9
eClass 6.1	30220300
eClass 9.0	32160605
Available
Alias	BAY 80-6946 (dihydrochloride)
Purity	99.55
Product Description	Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib dihydrochloride has more than 2, 000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib dihydrochloride has superior antitumor activity[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	553.44
Clinical_Information	Launched
Manufacturers Research Area	Cancer
Solubility	DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 50 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; PI3K
Isoform	PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
Pathway	Apoptosis; PI3K/Akt/mTOR

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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