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TMX-4153

TMX-4153

Item no.	HY-153119-5mg
Manufacturer	MedChem Express
CASRN	2867519-91-1
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.96
Formula	C59H67ClN10O6S
Citations	[1]Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angew Chem Int Ed Engl. 2023 Apr 24;62(18):e202302364.
Smiles	ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N(C5=O)CCC5(CC6)CCN6C(CCCCCC(N[C@H](C(N7[C@H](C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)C[C@@H](O)C7)=O)C(C)(C)C)=O)=O)=CN=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	TMX-4153 is a bivalent degrader. TMX-4153 rapidly and selectively degrades endogenous PIP4K2C by recruiting the von Hippel-Lindau (VHL) E3 ligase complex, with a KD value of 42 nM. TMX-4153 can be used to synthesize PROTAC[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
MolecularWeight	1079.74
Clinical Information	No Development Reported
Manufacturers Research Area	Others
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Ligands for Target Protein for PROTAC
Manufacturers Target	Ligands for Target Protein for PROTAC
Manufacturers Pathway	PROTAC
Manufacturers Product type	Reference compound

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