EVT801

Item no.	HY-152293-100mg
Manufacturer	MedChem Express
CASRN	1412453-70-3
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C19H21N5O3
Citations	[1]Paillasse M R, et al. Targeting Tumor Angiogenesis with the Selective VEGFR-3 Inhibitor EVT801 in Combination with Cancer Immunotherapy[J]. Cancer Research Communications, 2022, 2(11): 1504-1519.
Smiles	O=C1C(C2=NC=CN2)=C(N(C3=NC(C#C[C@@](C)(O)COC)=CC=C31)CC)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	EVT801 is an orally active and selective inhibitor of VEGFR-3 (IC50=11 nM), which has antitumor effects. EVT801 inhibits not only VEGF-C-induced human endothelial cell proliferation, but also tumor (lymphatic) angiogenesis in tumor mouse models. EVT801 can reduce tumor hypoxia, immunosuppressive cytokines (CCL4, CCL5) and myeloid derived suppressor cells (MDSC) production. EVT801 has synergistic effect with immune checkpoint therapy (ICT), which improves ICT response rate and has better inhibitory effect on cancer mouse models[1]. EVT801 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Shipping	Room temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	367.40
Clinical Information	Phase 1
Manufacturers Research Area	Cancer
Solubility	10 mM in DMSO
Target	ERK; VEGFR
Manufacturers Target	ERK; VEGFR
Isoform	ERK; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Manufacturers Pathway	MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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