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MS15 (TFA)

MS15 (TFA)

Item no.	HY-151613A-1mg
Manufacturer	MedChem Express
Amount	1 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.86
Formula	C66H80F3N11O7S
Dry ice	Yes
Citations	[1]Yu X, et al. Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells. J Med Chem. 2022 Oct 27;65(20):14237-14260.
Smiles	NC1(CCC1)C(C=C2)=CC=C2N3C4=NC(C5=CC(CCC(NCCCCCCCCCCC(N[C@H](C(N6C[C@@H](C[C@H]6C(N[C@@H](C)C7=CC=C(C=C7)C8=C(N=CS8)C)=O)O)=O)C(C)(C)C)=O)=O)=CC=C5)=CC=C4N=C3C9=CC=CN=C9N.OC(C(F)(F)F)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	MS15 TFA is a potent and selective AKT PROTAC degrader. MS15 TFA inhibits the AKT1, -2, and -3 activities, with IC50 values of 798 nM, 90 nM, and 544 nM, respectively[1].
StorageTemperature	-80°C, protect from light, stored under nitrogen
Shipping	Dry Ice
MolecularWeight	1228.47
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL
Manufacturers Target	Akt; PROTACs
Pathway	PI3K/Akt/mTOR; PROTAC
Manufacturers Product type	Reference compound

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