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SOS1-IN-14

SOS1-IN-14

Item no.	HY-151517-25mg
Manufacturer	MedChem Express
CASRN	2793405-20-4
Amount	25 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.38
Formula	C29H29F3N6O2
Citations	[1]He H, et al. Discovery of Orally Bioavailable SOS1 Inhibitors for Suppressing KRAS-Driven Carcinoma. J Med Chem. 2022 Sep 29.
Smiles	N#CC1(C(N2C[C@]3([H])CCOC4=CC5=NC(C)=NC(N[C@@H](C6=CC=CC(C(F)F)=C6F)C)=C5C=C4N3CC2)=O)CC1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	SOS1-IN-14 is a potent, selective and orally active SOS1 inhibitor with an IC50 value of 3.9 nM. SOS1-IN-14 can be absorbed in the intestine via a P-glycoprotein-mediated efflux mechanism. SOS1-IN-14 can be used to research KRAS-mutated cancers. SOS1-IN-14 has better potent tumor suppression than BI-3406 (HY-125817)[1].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	550.57
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 250 mg/mL (ultrasonic)
Manufacturers Target	Ras
Pathway	GPCR/G Protein; MAPK/ERK Pathway
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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