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STAT3-IN-13

STAT3-IN-13

Item no.	HY-150603-1ea
Manufacturer	MedChem Express
CASRN	2248552-86-3
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.01
Citations	[1]Jin W, et, al. Discovery of 2-Amino-3-cyanothiophene Derivatives as Potent STAT3 Inhibitors for the Treatment of Osteosarcoma Growth and Metastasis. J Med Chem. 2022 May 12;65(9):6710-6728.
Smiles	N#CC1=C(SC2=C1CCN(C2)C(NC3=CC=C(C=C3)OC)=O)NC(C(C=N4)=CN4C)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	STAT3-IN-13 (compound 6f) is a potent STAT3 inhibitor. STAT3-IN-13 has anti-proliferative effects and binds to the STAT3 SH2 domain with a KD of 0.46 μM. STAT3-IN-13 inhibits the phosphorylation of STAT3 Y705 and downstream target gene expression. STAT3-IN-13 induces apoptosis in vitro and suppresses the growth and metastasis of tumor in vivo. STAT3-IN-13 can be used for cancer research[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	436.49
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 125 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; Bcl-2 Family; STAT
Pathway	Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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