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Diclofenac (diethylamine)

Diclofenac (diethylamine)

Item no.	HY-15036A-500mg
Manufacturer	MedChem Express
CASRN	78213-16-8
Amount	500 mg
Quantity options	10 g 10mM/1mL 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.96
Formula	C18H22Cl2N2O2
Citations	Pharm Res. 2022 Aug 24.<br/>Arch Microbiol. 2024 Jun 7;206(7):289.<br/>Biotechnol Bioeng. 2021 Sep 3.<br/>Phys Chem Chem Phys. 2016 Jan 21;18(3):1526-36. <br/>Toxicol Mech Methods. 2019 Nov;29(9):654-664.<br/>bioRxiv. 2024 Apr 7.<br/>Biotechnol Bioeng. 2021 Sep 3.<br/>Chem-Biol Interact. 2021, 109425.<br/>Chemosphere. 2019 Jun;225:378-387. <br/>Eur J Drug Metab Pharmacokinet. 2022 Jun 22.<br/>Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS). 2017 Nov.<br/>Int J Mol Sci. 2022, 23(20), 12066.<br/>J Hazard Mater. 2015 May 30;289:18-27.<br/>J Pharmaceut Biomed. 2021, 114105.<br/>J Phys Chem Solids. 2017 October;109:117-123.<br/>Biotechnol Bioeng. 2021 Sep 3.<br/>[1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.<br/>[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.<br/>[3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95.
Smiles	O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl.CCNCC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	78213-16-8
Available
Product Description	Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	369.29
Clinical Information	Launched
Manufacturers Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO : 150 mg/mL (ultrasonic)
Target	Apoptosis; COX
Manufacturers Target	Apoptosis; COX
Isoform	COX-1; COX-2
Manufacturers Pathway	Apoptosis; Immunology/Inflammation
Manufacturers Product type	Reference compound

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HY-15036A-500mg-safety-datasheet.pdf