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Thalidomide-5-O-C5-NH2 (hydrochloride)

Thalidomide-5-O-C5-NH2 (hydrochloride)

Item no.	HY-149562-10mg
Manufacturer	MedChem Express
CASRN	2761385-94-6
Amount	10 mg
Quantity options	10 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.90
Formula	C18H22ClN3O5
Citations	[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief]
Smiles	O=C1C(C=CC(OCCCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Thalidomide-5-O-C5-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].
StorageTemperature	-20°C (Powder, protect from light, stored under nitrogen)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	395.84
Clinical Information	No Development Reported
Manufacturers Research Area	cancer
Solubility	10 mM in DMSO
Target	Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Manufacturers Target	Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Isoform	Cereblon
Manufacturers Pathway	Apoptosis; Autophagy; PROTAC
Manufacturers Product type	Reference compound

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