Item no. |
HY-14933-5mg |
Manufacturer |
MedChem Express
|
CASRN |
524684-52-4 |
Amount |
5 mg |
Quantity options |
10mM/1mL
10 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
98.05 |
Formula |
C15H10FNO3 |
Citations |
[1]Malamas MS, et al. Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands. J Med Chem. 2004;47(21):5021-5040.<br/>[2]Chaudhary SC, et al. Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014;7(2):186-198.<br/>[3]Chan KKL, et al. Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K/AKT signaling in ovarian cancer. Cancer Cell Int. 2018;18:65. Published 2018 May 1. |
Smiles |
OC1=CC(C=C)=C(OC(C2=CC=C(O)C(F)=C2)=N3)C3=C1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
ERB-041 |
Available |
|
Product Description |
Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer apoptosis[1][2][3]. |
StorageTemperature |
-20°C, 3 years; 4°C, 2 years (Powder) |
Shipping |
Room Temperature |
Manufacturers Applications |
Cancer-programmed cell death |
MolecularWeight |
271.24 |
Clinical Information |
Phase 2 |
Manufacturers Research Area |
Cancer |
Solubility |
DMSO : ≥ 40 mg/mL |
Target |
Apoptosis; Estrogen Receptor/ERR; Wnt |
Manufacturers Target |
Apoptosis; Estrogen Receptor/ERR; Wnt |
Isoform |
ERα; ERβ |
Manufacturers Pathway |
Apoptosis; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.