MTX-23

Item no.	HY-148771-25mg
Manufacturer	MedChem Express
CASRN	2488296-74-6
Amount	25 mg
Quantity options	10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.90
Formula	C43H53F2N7O7S2
Citations	[1]Jenny D, et, al. Bi-functional compounds and methods for targeted ubiquitination of androgen receptor. WO2021236695.
Smiles	O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PROTAC AR-V7 degrader-2
Available
Product Description	MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	882.05
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Androgen Receptor; Apoptosis; PROTACs
Manufacturers Target	Androgen Receptor; Apoptosis; PROTACs
Manufacturers Pathway	Apoptosis; PROTAC; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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