MS8815

Item no.	HY-148334-10mM
Manufacturer	MedChem Express
CASRN	2855085-25-3
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mM x 1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.79
Formula	C65H87N9O8S
Citations	[1]Brandon Dale, et al. Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2. ACS Pharmacol Transl Sci. 2022 Jun 24;5(7):491-507.
Smiles	CC(C=C(C)N1)=C(CNC(C2=C(C)C(N(CC)C3CCOCC3)=CC(C4=CC=C(CN5CCN(C(CCCCCCCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](O)C6)=O)=O)=O)CC5)C=C4)=C2)=O)C1=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	MS8815 is a selective enhancer of zeste homolog 2 (EZH2) PROTAC degrader. MS8815 has inhibition activity for EZH2 with an IC50 value of 8.6 nM. MS8815 can be used for the research of triple-negative breast cancer (TNBC)[1].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	1154.51
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 120 mg/mL (ultrasonic)
Target	Histone Methyltransferase; PROTACs
Manufacturers Target	Histone Methyltransferase; PROTACs
Manufacturers Pathway	Epigenetics; PROTAC
Manufacturers Product type	Reference compound

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