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Lorundrostat

Lorundrostat

Item no.	HY-147277-10mg
Manufacturer	MedChem Express
CASRN	1820940-17-7
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 ea 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	99.37
Formula	C24H33N7O2
Citations	[1]International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022.<br/>[2]Laffin LJ, et al. Aldosterone Synthase Inhibition With Lorundrostat for Uncontrolled Hypertension: The Target-HTN Randomized Clinical Trial. JAMA. 2023 Sep 26;330(12):1140-1150
Smiles	CC(N[C@@H](CC1)CC[C@H]1NC(CN2CCN(CC2)C3=NN=CC(C4=CC=C(C=C4)C)=N3)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MT-4129
Available
Product Description	Lorundrostat (MT-4129) is an orally active aldosterone synthase inhibitor. Lorundrostat can be used in studies of high blood pressure[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-sugar/lipid metabolism
MolecularWeight	451.56
Clinical Information	Phase 3
Manufacturers Research Area	Cardiovascular Disease
Solubility	DMSO : 33.33 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Target	Mineralocorticoid Receptor
Manufacturers Target	Mineralocorticoid Receptor
Manufacturers Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Manufacturers Product type	Reference compound

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