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Avacincaptad pegol sodium

Avacincaptad pegol sodium

Item no.	HY-147080-10mg
Manufacturer	MedChem Express
CASRN	1491144-00-3
Amount	10 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.53
Formula	C395H453F21N142Na39O262P39 (C2H4O)2n
Citations	[1]Powers, J. P., Dairaghi, D. J., & Jaen, J. C. (2011). Advances in the Discovery of C5a Receptor Antagonists. Annual Reports in Medicinal Chemistry, 171–186. <br>[2]Jaffe GJ, Westby K, Csaky KG, et al. C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration: A Randomized Pivotal Phase 2/3 Trial. Ophthalmology. 2021;128(4):576-586. <br>[3]Patel SS, Lally DR, Hsu J, et al. Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial [published online ahead of print, 2023 Mar 24]. Eye (Lond). 2023;10.1038/s41433-023-02497-w.
Smiles	[Avacincaptad pegol sodium]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ARC1905
Available
Product Description	Avacincaptad pegol (ARC1905) is an anti-C5 RNA aptamer that inhibits the cleavage of complement factor 5 (C5) into C5a and C5b. Avacincaptad pegol is being used for the study of age-related macular degeneration (AMD).
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	53500 (Approximately)
Clinical_Information	Launched
Manufacturers Research_Area	Others
Solubility	H2O : 100 mg/mL (ultrasonic)
Manufacturers Target	Complement System
Pathway	Immunology/Inflammation
Manufacturers Product type	Oligonucleotides

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Amount: 10 mg

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