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BRD4 Inhibitor-18

BRD4 Inhibitor-18

Item no.	HY-146660-100mg
Manufacturer	MedChem Express
CASRN	2451219-73-9
Amount	100 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Li Q, Li J, Cai Y, et al. Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo[c]thiazolo[4,5-e]azepin-2-one derivatives as potential BRD4 inhibitors. Bioorg Med Chem. 2020;28(15):115601.
Smiles	COC1=CC2=C(C=C1)C3=C(SC(N3C)=O)C(CC(NC4CCCC4)=O)N=C2C5=CC=C(Cl)C=C5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with an IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity[1].
Shipping	Room temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	496.02
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	10 mM in DMSO
Isoform	BRD4
Pathway	Apoptosis; Epigenetics
Manufacturers Product type	Reference compound

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