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Aspirin-d4

Aspirin-d4

Item no.	HY-14654S1-10mM
Manufacturer	MedChem Express
CASRN	97781-16-3
Amount	10 mM x 1 mL
Quantity options	10 mM x 1 mL 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.08
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. <br/>[2]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7.<br/>[3]Vane JR, et al. The mechanism of action of aspirin. Thromb Res. 2003 Jun 15;110(5-6):255-8.<br/>[4]Wu KK, et al. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12.<br/>[5]Kopp E, et al. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265(5174):956-9.<br/>[6]Blanco FJ, et al. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26(6):1366-73.
Smiles	OC(C1=C(C([2H])=C([2H])C([2H])=C1[2H])OC(C)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Acetylsalicylic Acid-d4; ASA-d4
Available
Product Description	Aspirin-d4 is the deuterium labeled Aspirin. Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
MolecularWeight	184.18
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Autophagy; COX; Mitophagy; Virus Protease
Manufacturers Target	Autophagy; COX; Mitophagy; Virus Protease
Manufacturers Pathway	Anti-infection; Autophagy; Immunology/Inflammation
Manufacturers Product type	Isotope-Labeled Compounds

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Amount: 10 mM x 1 mL

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