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KRAS inhibitor-18

KRAS inhibitor-18

Item no.	HY-146476-1ea
Manufacturer	MedChem Express
CASRN	2230873-66-0
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C20H15ClF3N3O2S
Citations	[1]Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2
Smiles	C=CC(N1CCN(CC1)C2=C3C=C(C(C4=CC(O)=C(C=C4F)F)=C(C3=NS2)F)Cl)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	KRAS inhibitor-18 (compound 3-10) is a potent KRAS G12C inhibitor with an IC50 of 4.74 µM. KRAS inhibitor-18 shows p-ERK inhibition activities with IC50s of 66.4, 11.1 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-18 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
Shipping	Room temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	453.87
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	10 mM in DMSO
Manufacturers Target	Ras
Isoform	K-Ras
Pathway	GPCR/G Protein; MAPK/ERK Pathway
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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