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Topoisomerase II inhibitor 7

Topoisomerase II inhibitor 7

Item no.	HY-146163-100mg
Manufacturer	MedChem Express
CASRN	2697171-03-0
Amount	100 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Nemr MTM, et, al. Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity. Bioorg Chem. 2020 Dec;105:104446.
Smiles	O=C(C1=C(C2=CC=CC=C2)N=C3SC4=C(N3C1C5=CC(OC)=C(C(OC)=C5)OC)N=C(N)N=C4C6=CC=C(Br)C=C6)OCC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Topoisomerase II inhibitor 7 (compound 3a) is a potent inhibitor of topoisomerase II alpha subtype, with an IC50 of 3.19 μM. Topoisomerase II inhibitor 7 can induce cell cycle arrest and apoptosis[1].
Shipping	Room temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	674.56
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	10 mM in DMSO
Manufacturers Target	Apoptosis; Topoisomerase
Isoform	Topo II
Pathway	Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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Amount: 100 mg

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