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α7 nAchR-JAK2-STAT3 agonist 1

α7 nAchR-JAK2-STAT3 agonist 1

Item no.	HY-146066-50mg
Manufacturer	MedChem Express
CASRN	2108714-20-9
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C25H30O6
Citations	[1]Lin Y, et al. Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo. Bioorg Med Chem. 2022;66:116811.
Smiles	O=C(O[C@@H](CCCCC1=CC=CC=C1)CCC2=CC=C(OC(C)=O)C(OC(C)=O)=C2)C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis[1].
Shipping	Room temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	426.50
Clinical Information	No Development Reported
Manufacturers Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Target	JAK; nAChR; NO Synthase; STAT
Manufacturers Target	JAK; nAChR; NO Synthase; STAT
Isoform	iNOS
Manufacturers Pathway	Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Membrane Transporter/Ion Channel; Neuronal Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Manufacturers Product type	Reference compound

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