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OARV-771

OARV-771

Item no.	HY-145264-10mM*1mL
Manufacturer	MedChem Express
CASRN	2683008-37-7
Amount	10 mM x 1 mL
Quantity options	100 mg 10mM/1mL 10 mM x 1 mL 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.33
Citations	[1]Klein VG, et al. Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity. J Med Chem. 2021;64(24):18082-18101.
Smiles	CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@@H](CC(OCCOCCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)C7=NN=C(C)N27
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	OARV-771 is a VHL-based BET degrader (PROTAC) with improved cell permeability. OARV-771 shows DC50s of 6, 1, and 4 nM for Brd4, Brd2 and Brd3, respectively[1].
StorageTemperature	-20°C (Powder, sealed storage, away from moisture)
Shipping	Blue Ice
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	987.62
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Target	Epigenetic Reader Domain; PROTACs
Manufacturers Target	Epigenetic Reader Domain; PROTACs
Isoform	BRD2; BRD3; BRD4; von Hippel-Lindau (VHL)
Manufacturers Pathway	Epigenetics; PROTAC
Manufacturers Product type	Reference compound

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Amount: 10 mM x 1 mL

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