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Methotrexate (disodium)

Methotrexate (disodium)

Item no.	HY-14519A-500mg
Manufacturer	MedChem Express
CASRN	7413-34-5
Amount	500 mg
Quantity options	100 mg 10mM/1mL 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.71
Formula	C20H20N8Na2O5
Citations	[1]Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73.<br/>[2]Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92.<br/>[3]Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92.<br/>[4]Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550.
Smiles	NC1=NC(N)=C2C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O[Na])=O)C(O[Na])=O)=O)C=C3)=N2)=N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Amethopterin (disodium); CL14377 (disodium); WR19039 (disodium)
Similar products	7413-34-5
Available
Product Description	Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	498.40
Clinical Information	Launched
Manufacturers Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 5 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C)\|H2O : 50 mg/mL (ultrasonic)
Target	ADC Cytotoxin; Antifolate; Apoptosis; Bacterial; DNA/RNA Synthesis
Manufacturers Target	ADC Cytotoxin; Antifolate; Apoptosis; Bacterial; DNA/RNA Synthesis
Isoform	Traditional Cytotoxic Agents
Manufacturers Pathway	Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type	ADC Related

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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