Item no. |
HY-14519A-100mg |
Manufacturer |
MedChem Express
|
CASRN |
7413-34-5 |
Amount |
100 mg |
Quantity options |
100 mg
10mM/1mL
500 mg
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.71 |
Formula |
C20H20N8Na2O5 |
Citations |
[1]Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73.<br/>[2]Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92.<br/>[3]Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92.<br/>[4]Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550. |
Smiles |
NC1=NC(N)=C2C(N=CC(CN(C)C3=CC=C(C(N[C@@H](CCC(O[Na])=O)C(O[Na])=O)=O)C=C3)=N2)=N1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Amethopterin (disodium); CL14377 (disodium); WR19039 (disodium) |
Similar products |
7413-34-5 |
Available |
|
Product Description |
Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture and light) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-anti-virus |
MolecularWeight |
498.40 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Inflammation/Immunology |
Solubility |
DMSO : 5 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C)|H2O : 50 mg/mL (ultrasonic) |
Target |
ADC Cytotoxin; Antifolate; Apoptosis; Bacterial; DNA/RNA Synthesis |
Manufacturers Target |
ADC Cytotoxin; Antifolate; Apoptosis; Bacterial; DNA/RNA Synthesis |
Isoform |
Traditional Cytotoxic Agents |
Manufacturers Pathway |
Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage |
Manufacturers Product type |
ADC Related |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.