Item no. |
HY-14397-500mg |
Manufacturer |
MedChem Express
|
CASRN |
53-86-1 |
Amount |
500 mg |
Quantity options |
100 mg
10mM/1mL
1 g
500 mg
5 g
|
Category |
|
Type |
Inhibitors |
Specific against |
other |
Purity |
99.97 |
Formula |
C19H16ClNO4 |
Citations |
[1]Riendeau D, et, al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.<br/>[2]Eli Y, et, al. Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo. Biochem Pharmacol. 2001 Mar 1;61(5):565-71.<br/>[3]Amici C, et, al. Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2α kinase PKR. Cell Microbiol. 2015 Sep;17(9):1391-404.<br/>[4]Helleberg L, et, al. Clinical Pharmacokinetics of indomethacin. Clin Pharmacokinet. 1981 Jul-Aug;6(4):245-58.<br/>[5]Sabiu S, et, al. Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin a nd Ficus exasperate. Toxicol Rep. 2015 Jan 8:2:261-267.<br/>[6]Danisman B, et, al, Carnosic Acid Ameliorates Indomethacin-Induced Gastric Ulceration in Rats by Alleviating Oxidative Stress and Inflammation. Biomedicines. 2023 Mar 9;11(3):829. |
Smiles |
COC1=CC=C(N(C(C2=CC=C(Cl)C=C2)=O)C(C)=C3CC(O)=O)C3=C1 |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
Indometacin |
Available |
|
Product Description |
Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research[1][2][3]. |
StorageTemperature |
4°C (Powder, protect from light) |
Shipping |
Room Temperature |
Manufacturers Applications |
COVID-19-immunoregulation |
MolecularWeight |
357.79 |
Clinical Information |
Launched |
Manufacturers Research Area |
Cancer; Inflammation/Immunology |
Solubility |
DMSO : 100 mg/mL (ultrasonic)|Ethanol : 12.5 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL |
Target |
Antibiotic; Bacterial; COX; Influenza Virus |
Manufacturers Target |
Antibiotic; Bacterial; COX; Influenza Virus |
Isoform |
COX-1; COX-2 |
Manufacturers Pathway |
Anti-infection; Immunology/Inflammation |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.