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(R)-V-0219 (hydrochloride)

(R)-V-0219 (hydrochloride)

Item no.	HY-143312D-25mg
Manufacturer	MedChem Express
Amount	25 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.37
Formula	C20H26ClF3N4O2
Citations	[1]Decara JM, et al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". J Med Chem. 2022 Apr 14;65(7):5449-5461.
Smiles	FC(C1=CC=C(C2=NOC(CN3C[C@@H](CN4CCOCC4)CCC3)=N2)C=C1)(F)F.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	(R)-V-0219 hydrochloride is an enantiomer of V-0219 (HY-143312). V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (R)-V-0219 hydrochloride activates calcium fluxes in HEK cells stably expressing hGLP-1R[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Metabolism-protein/nucleotide metabolism
MolecularWeight	446.89
Clinical Information	No Development Reported
Manufacturers Research Area	Metabolic Disease
Solubility	DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Target	GLP Receptor
Manufacturers Target	GLP Receptor
Manufacturers Pathway	GPCR/G Protein
Manufacturers Product type	Reference compound

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