Comparison

AS-99 (free base) European Partner

Item no. HY-141429-50mg
Manufacturer MedChem Express
CASRN 2323623-93-2
Amount 50 mg
Quantity options 100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category
Type Molecules
Specific against other
Citations [1]David S. Rogawski, Jing Deng, Hao Li, Tomasz Cierpicki, Jolanta Grembecka, et al. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun. 2021 May 14;12(1):2792.
Smiles O=C(C1CN(C)C1)NCC2=CC3=C(C=C2)C(C4=CC=CC(C(N)=S)=C4)=CN3C5CCN(S(=O)(C(F)(F)F)=O)CC5
ECLASS 10.1 32169090
ECLASS 11.0 32169090
UNSPSC 12000000
Available
Product Description
AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo[1].
Shipping
Room temperature
Manufacturers Applications
Cancer-programmed cell death
MolecularWeight
593.68
Clinical Information
No Development Reported
Manufacturers Research Area
Cancer
Solubility
10 mM in DMSO
Target
Apoptosis; Histone Methyltransferase
Manufacturers Target
Apoptosis; Histone Methyltransferase
Isoform
ASH1L/KMT2H
Manufacturers Pathway
Apoptosis; Epigenetics
Manufacturers Product type
Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 mg
Available: In stock
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