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Opnurasib

Opnurasib

Item no.	HY-139612-100mg
Manufacturer	MedChem Express
CASRN	2653994-08-0
Amount	100 mg
Quantity options	100 mg 10mM/1mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.94
Citations	[1]LIU BO, et al. PYRAZOLYL DERIVATIVES USEFUL AS ANTI-CANCER AGENTS. Patent WO2021120890A1.<br/>[2][2] Weiss A, Lorthiois E, Barys L, et al. Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent and Selective, Covalent Oral Inhibitor of KRASG12C. Cancer Discov. 2022;candisc.0158.2022.
Smiles	O=C(N1CC2(CC(C2)N3N=C([C@]([C@]4=C(Cl)C(C)=CC5=C4C=NN5)=C3C)C6=CC=C7C(C=NN7C)=C6)C1)C=C
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	JDQ-443; NVP-JDQ443
Available
Product Description	Opnurasib (JDQ-443) (NVP-JDQ443) is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). Opnurasib shows antitumor activity[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	526.03
Clinical Information	Phase 3
Manufacturers Research Area	Cancer
Solubility	DMSO : 80 mg/mL (ultrasonic)
Target	PERK; Ras
Manufacturers Target	PERK; Ras
Isoform	K-Ras
Manufacturers Pathway	Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway
Manufacturers Product type	Reference compound

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