Item no. |
HY-139576B-10mg |
Manufacturer |
MedChem Express
|
Amount |
10 mg |
Quantity options |
100 mg
10mM/1mL
10 mg
1 ea
25 mg
50 mg
5 mg
|
Category |
|
Type |
Inhibitor |
Specific against |
other |
Purity |
97.0 |
Formula |
C27H46O5S.0.45C3H9N |
Citations |
[1]Ren S, et, al. Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes. Biochem Biophys Res Commun. 2007 Sep 7;360(4):802-8.<br/>[2]Ma Y, et, al. 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway. Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1369-79.<br/>[3]Xu L, et, al. 5-cholesten-3β,25-diol 3-sulfate decreases lipid accumulation in diet-induced nonalcoholic fatty liver disease mouse model. Mol Pharmacol. 2013 Mar;83(3):648-58. |
Smiles |
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)OS(=O)(O)=O)=CC3)C.CN(C)C.[0.45] |
ECLASS 10.1 |
32160490 |
ECLASS 11.0 |
32160490 |
UNSPSC |
12000000 |
Alias |
DUR-928 (trimethylamine) |
Available |
|
Product Description |
Larsucosterol (DUR-928) trimethylamine, a cholesterol metabolite, is a potent liver X receptor (LXR) antagonist. Larsucosterol trimethylamine as a potent endogenous regulator decreases lipogenesis. Larsucosterol trimethylamine inhibits the cholesterol biosynthesis via decreasing mRNA levels and inhibiting the activation of SREBP-1[1][2][3]. |
StorageTemperature |
4°C (Powder, sealed storage, away from moisture) |
Shipping |
Room Temperature |
Manufacturers Applications |
Metabolism-sugar/lipid metabolism |
MolecularWeight |
509.32 |
Clinical Information |
Phase 2 |
Manufacturers Research Area |
Metabolic Disease |
Solubility |
DMSO : 33.33 mg/mL (ultrasonic) |
Target |
Endogenous Metabolite; LXR |
Manufacturers Target |
Endogenous Metabolite; LXR |
Manufacturers Pathway |
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor |
Manufacturers Product type |
Reference compound |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.