NiCur

Item no.	HY-139149-5mg
Manufacturer	MedChem Express
CASRN	2674753-39-8
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.11
Formula	C22H16N2O
Citations	[1]Vincek AS, et al. Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3. Molecules. 2018;23(8):1930. Published 2018 Aug 2.
Smiles	N#CC1=CC=CC(/C=C2C(/C(CCC/2)=C/C3=CC(C#N)=CC=C3)=O)=C1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	NiCur is a potent and selective CBP histone acetyltransferase (HAT) inhibitor with an IC50 value of 0.35 μΜ. NiCur, which blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur can be used for performing mechanistic studies without affecting the expression of target proteins[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	324.38
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)
Manufacturers Target	Histone Acetyltransferase
Isoform	CBP/p300
Pathway	Epigenetics
Manufacturers Product type	Reference compound

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