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Iclepertin

Iclepertin

Item no.	HY-138935-10mg
Manufacturer	MedChem Express
CASRN	1421936-85-7
Amount	10 mg
Quantity options	100 mg 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.97
Formula	C20H18F6N2O5S
Citations	[1]Holger Rosenbrock, et al. Evaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies. Clin Transl Sci. 2018 Nov;11(6):616-623.
Smiles	O=C(C1=C(C=CC(S(C)(=O)=O)=C1)O[C@H](C)C(F)(F)F)N2C[C@]3(C4=NOC(C(F)(F)F)=C4)[C@@](C2)([H])C3
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	BI-425809
Available
Product Description	Iclepertin (BI-425809) is a potent, selective and orally active glycine transporter 1 (GlyT1) inhibitor. Iclepertin is inactive against GlyT2. Iclepertin can be used for Alzheimer disease and schizophrenia research[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	512.42
Clinical Information	Phase 3
Manufacturers Research Area	Neurological Disease
Solubility	DMSO : 11.36 mg/mL (ultrasonic; warming; heat to 60°C)
Target	GlyT
Manufacturers Target	GlyT
Isoform	GlyT1
Manufacturers Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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