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Thalidomide-Piperazine-Piperidine

Thalidomide-Piperazine-Piperidine

Item no.	HY-138783-50mg
Manufacturer	MedChem Express
CASRN	2229716-11-2
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Citations	[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.<br/>[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008.
Smiles	O=C1C(CCC(N1)=O)N2C(C3=C(C=CC(N4CCN(CC4)C5CCNCC5)=C3)C2=O)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	Thalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Shipping	Room temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	425.48
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	10 mM in DMSO
Target	Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Manufacturers Target	Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Isoform	Cereblon
Manufacturers Pathway	Apoptosis; Autophagy; PROTAC
Manufacturers Product type	Reference compound

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