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EFdA-TP (tetraammonium)

EFdA-TP (tetraammonium)

Item no.	HY-138561A-25mg
Manufacturer	MedChem Express
Amount	25 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	98.03
Citations	[1]Martin Markowitz, et al. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine, MK-8591: a novel HIV-1 reverse transcriptase translocation inhibitor. Curr Opin HIV AIDS. 2018 Jul;13(4):294-299.<br/>[2]Eleftherios Michailidis, et al. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms. J Biol Chem. 2014 Aug 29;289(35):24533-48.
Smiles	O=[P](O[P](O[P](O)(O)=O)(O)=O)(O)OC[C@]1(O[C@@](C[C@@H]1O)([H])N2C3=NC(F)=NC(N)=C3N=C2)C#C.N.N.N.N
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	EFdA-TP tetraammonium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetraammonium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetraammonium inhibits HIV-1 RT with multiple mechanisms[1]. EFdA-TP (tetraammonium) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
StorageTemperature	-20°C (Powder, sealed storage, away from moisture and light)
Shipping	Blue Ice
Manufacturers Applications	COVID-19-anti-virus
MolecularWeight	601.32
Clinical Information	No Development Reported
Manufacturers Research Area	Infection
Solubility	10 mM in DMSO
Target	DNA/RNA Synthesis; HIV; Reverse Transcriptase
Manufacturers Target	DNA/RNA Synthesis; HIV; Reverse Transcriptase
Isoform	HIV-1
Manufacturers Pathway	Anti-infection; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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Amount: 25 mg

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