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Atovaquone-d5

Atovaquone-d5

Item no.	HY-13832S2-5mg
Manufacturer	MedChem Express
CASRN	1329792-63-3
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. <br>[2]Nilsen A, et al. Quinolone-3-diarylethers: a new class of antimalarial drug.Sci Transl Med. 2013 Mar 20;5(177):177ra37.<br>[3]Schöler N, et al. Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis.Antimicrob Agents Chemother. 2001 Jun;45(6):1771-9.
Smiles	O=C1C([C@@]2([2H])C([2H])([2H])C[C@H](C3=CC=C(C=C3)Cl)CC2([2H])[2H])=C(C(C4=CC=CC=C41)=O)O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Atavaquone-d5
Available
Product Description	Atovaquone-d5 is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].
Shipping	Room temperature
MolecularWeight	371.87
Clinical_Information	No Development Reported
Manufacturers Research_Area	Infection
Solubility	10 mM in DMSO
Manufacturers Target	Antibiotic; Cytochrome P450; Isotope-Labeled Compounds; Parasite
Isoform	Plasmodium
Pathway	Anti-infection; Metabolic Enzyme/Protease; Others
Manufacturers Product type	Isotope-Labeled Compounds

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