SIC5-6

Item no.	HY-138084-100mg
Manufacturer	MedChem Express
CASRN	2410846-16-9
Amount	100 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.82
Formula	C27H24IN3O2S
Citations	[1]Henschke L, et al. Identification of Bioactive Small Molecule Inhibitors of Separase. ACS Chem Biol. 2019 Oct 18;14(10):2155-2159.
Smiles	O=[S](N1CCC(C2=CNC3=CC=CC=C23)(C4=CNC5=CC=CC=C45)CC1)(C(C=C6)=CC=C6I)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	581.47
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturers Target	Separase
Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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