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KRAS inhibitor-9

KRAS inhibitor-9

Item no.	HY-137497-1mg
Manufacturer	MedChem Express
CASRN	300809-71-6
Amount	1 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.85
Formula	C13H9ClN2S2
Citations	[1]Xie C, et al. Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells. Front Pharmacol. 2017;8:823. Published 2017 Nov 14.
Smiles	NC1=CC=C(SC2=NC3=CC=CC=C3S2)C(Cl)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	KRAS inhibitor-9, a potent KRAS inhibitor (Kd=92 μM), blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 binds to KRAS G12D, KRAS G12C and KRAS Q61H protein with a moderate binding affinity. KRAS inhibitor-9 causes G2/M cell cycle arrest and induces apoptosis. KRAS inhibitor-9 selectively inhibits the proliferation of NSCLC cells with KRAS mutation but not normal lung cells[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	292.81
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 250 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; Ras
Pathway	Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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