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1,2'-O-Dimethylguanosine

1,2'-O-Dimethylguanosine

Item no.	HY-137406-1ea
Manufacturer	MedChem Express
CASRN	73667-71-7
Amount	1 ea
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C12H17N5O5
Citations	[1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.
Smiles	OC[C@@H]1[C@@H](O)[C@@H](OC)[C@H](N(C=N2)C3=C2C(N(C)C(N)=N3)=O)O1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	1, 2'-O-Dimethylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
Shipping	Room temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	311.29
Clinical Information	No Development Reported
Manufacturers Research Area	Others
Solubility	10 mM in DMSO
Target	Nucleoside Antimetabolite/Analog
Manufacturers Target	Nucleoside Antimetabolite/Analog
Manufacturers Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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