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Pirarubicin (Hydrochloride)

Pirarubicin (Hydrochloride)

Item no.	HY-13725A-5mg
Manufacturer	MedChem Express
CASRN	95343-20-7
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.56
Formula	C32H38ClNO12
Citations	Cancer Drug Resist. 2020 Sep 12. <br>Heliyon. June 2022, e09643.<br>Int J Pharm. 2022 May 25;620:121761.<br>J Mol Liq. 2020, 114633.<br>J Mol Liq. 2023 Jun 12, 122324.<br>University of Paris. 2022 Sep 19.<br>Cancers (Basel). 2023 Apr 26, 15(9), 2487.<br>E3S Web of Conferences. 233, 02010 (2021).<br>Genomics. 2021 Nov 26;S0888-7543(21)00410-9.<br>Int J Hyperthermia. 2024 Feb 12;41(1):2316085.<br>Int J Mol Med. 2023 May 17.<br>J Mol Med (Berl). 2019 Aug;97(8):1183-1193.<br>Mol Med Rep. 2024 May;29(5):84.<br>Toxicol Appl Pharmacol. 2023 Feb 3;462:116411.<br>[1]Takigawa N, et al. Cytotoxic effect of topoisomerase II inhibitors against adriamycin- and etoposide-resistant small cell lung cancer sublines. Gan To Kagaku Ryoho. 1993 May;20(7):929-35.<br>[2]Nagai K, et al. Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells, and comparison with those in Ehrlich ascites carcinoma cells. Cancer Chemother Pharmacol. 2002 Mar;49(3):244-50. Epub 2002 Jan 8.<br>[3]Li K, et al. Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells. Biochem Biophys Res Commun. 2015 May 1;460(2):380-5.<br>[4]Wang YD, et al. Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity. J Asian Nat Prod Res. 2017 Oct 27:1-13.
Smiles	O=C1C2=C(C=CC=C2OC)C(C3=C(O)C4=C([C@@H](O[C@@]5([H])C[C@H](N)[C@H](O[C@@]6([H])OCCCC6)[C@H](C)O5)C[C@@](C(CO)=O)(O)C4)C(O)=C31)=O.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	THP Hydrochloride
Available
Product Description	Pirarubicin Hydrochloride is an anthracycline antibiotics, acts as a topoisomerase II inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	664.10
Clinical_Information	Launched
Manufacturers Research_Area	Cancer; Infection
Solubility	DMSO : 20.83 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Antibiotic; Autophagy; Bacterial; Topoisomerase
Isoform	Topo II
Pathway	Anti-infection; Autophagy; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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