RA-9

Item no.	HY-136528-5mg
Manufacturer	MedChem Express
CASRN	919091-63-7
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.67
Formula	C19H15N3O5
Citations	[1]Coughlin K, et al. Small-molecule RA-9 inhibits proteasome-associated DUBs and ovarian cancer in vitro and in vivo via exacerbating unfolded protein responses. Clin Cancer Res. 2014;20(12):3174-3186.
Smiles	O=C1/C(CNC/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=C/C3=CC=C([N+]([O-])=O)C=C3
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	919091-63-7
Similar products	919091-63-7
Available
Product Description	RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor with favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation without impacting 20S proteasome proteolytic activity. RA-9 selectively induces onset of apoptosis in ovarian cancer cell lines and primary cultures derived from donors. RA-9 induces endoplasmic reticulum (ER)-stress responses in ovarian cancer cells[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	365.34
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 80°C)
Target	Apoptosis; Deubiquitinase
Manufacturers Target	Apoptosis; Deubiquitinase
Manufacturers Pathway	Apoptosis; Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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