DI-82

Item no.	HY-136499-5mg
Manufacturer	MedChem Express
CASRN	1638148-50-1
Amount	5 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitor
Specific against	other
Purity	98.76
Formula	C20H26N6O4S3
Citations	[1]Julian Nomme, et al. Structure-guided Development of Deoxycytidine Kinase Inhibitors With Nanomolar Affinity and Improved Metabolic Stability. J Med Chem. 2014 Nov 26;57(22):9480-94.<br/>[2]Helena Almqvist, et al. CETSA Screening Identifies Known and Novel Thymidylate Synthase Inhibitors and Slow Intracellular Activation of 5-fluorouracil. Nat Commun. 2016 Mar 24;7:11040.
Smiles	NC1=NC(S[C@H](C)C(N=C2C(C=C3OCCNS(=O)(C)=O)=CC=C3OC)=C(S2)C)=NC(N)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	510.65
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 120 mg/mL (ultrasonic)
Target	Others
Manufacturers Target	Others
Manufacturers Pathway	Others
Manufacturers Product type	Reference compound

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