iFSP1

Item no.	HY-136057-5mg
Manufacturer	MedChem Express
CASRN	150651-39-1
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.84
Formula	C20H13N5
Citations	[1]Doll S, et al. FSP1 is a glutathione-independent ferroptosis suppressor.Nature. 2019 Nov;575(7784):693-698.
Smiles	N#CC1=C(N)N2C3=CC=CC=C3N=C2C(C#N)=C1C4=CC=C(C)C=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S, 3R)-RSL3 (HY-100218A)[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	323.35
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	Ferroptosis
Pathway	Apoptosis
Manufacturers Product type	Reference compound

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