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Synucleozid

Synucleozid

Item no.	HY-135902-50mg
Manufacturer	MedChem Express
CASRN	502139-01-7
Amount	50 mg
Quantity options	100 mg 10 mg 1 ea 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Citations	[1]Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.
Smiles	N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(NC4=CC=C(C(N)=N)C=C4)C=C3)N2)N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	NSC 377363
Available
Product Description	Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein. Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson’s disease[1].
Shipping	Room temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	368.43
Clinical Information	No Development Reported
Manufacturers Research Area	Neurological Disease
Solubility	10 mM in DMSO
Target	DNA/RNA Synthesis
Manufacturers Target	DNA/RNA Synthesis
Manufacturers Pathway	Cell Cycle/DNA Damage
Manufacturers Product type	Reference compound

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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