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Desethyl chloroquine

Desethyl chloroquine

Item no.	HY-135811-1mg
Manufacturer	MedChem Express
CASRN	1476-52-4
Amount	1 mg
Quantity options	100 mg 1 ea 1 mg 2500 ug
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Formula	C16H22ClN3
Citations	[1]Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18(2):95-100.<br/>[2]Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3(2):159-74.<br/>[3]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.
Smiles	CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Product Description	Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity[1][2].
Shipping	Room temperature
Manufacturers Applications	COVID-19-immunoregulation
MolecularWeight	291.82
Clinical Information	No Development Reported
Manufacturers Research Area	Infection
Solubility	10 mM in DMSO
Target	Autophagy; Parasite; Toll-like Receptor (TLR)
Manufacturers Target	Autophagy; Parasite; Toll-like Receptor (TLR)
Isoform	Plasmodium
Manufacturers Pathway	Anti-infection; Autophagy; Immunology/Inflammation
Manufacturers Product type	Reference compound

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