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LDN-192960 (hydrochloride)

LDN-192960 (hydrochloride)

Item no.	HY-13455A-10mM
Manufacturer	MedChem Express
CASRN	2309172-48-1
Amount	10mM/1mL
Quantity options	10mM/1mL 10 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.78
Formula	C18H22Cl2N2O2S
Citations	Bioorg Chem. 2024 Apr 29:147:107412.<br/>Universidad de Córdoba. 2023 Sep 11.<br/>[1]Cuny GD, et al. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3491-4.<br/>[2]Gregory D Cuny, et al. Structure-activity Relationship Study of Acridine Analogs as Haspin and DYRK2 Kinase Inhibitors. Bioorg Med Chem Lett
Smiles	NCCCSC1=C(C=C(OC)C=C2)C2=NC3=CC=C(OC)C=C31.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2309172-48-1
Available
Product Description	LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	401.35
Clinical Information	No Development Reported
Manufacturers Research Area	Cancer
Solubility	DMSO : 7.14 mg/mL (ultrasonic)
Target	DYRK; Haspin Kinase
Manufacturers Target	DYRK; Haspin Kinase
Isoform	DYRK1; DYRK2
Manufacturers Pathway	Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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HY-13455A-10mM-safety-datasheet.pdf