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Capmatinib (dihydrochloride hydrate)

Capmatinib (dihydrochloride hydrate)

Item no.	HY-13404C-5mg
Manufacturer	MedChem Express
CASRN	1865733-40-9
Amount	5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.78
Formula	C23H21Cl2FN6O2
Citations	[1]Liu X, et al. A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin Cancer Res. 2011 Nov 15;17(22):7127-38.<br>[2]Baltschukat S, et al. Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation. Clin Cancer Res. 2019 May 15;25(10):3164-3175.<br>[3]Dhillon S. Capmatinib: First Approval. Drugs. 2020 Jul;80(11):1125-1131.
Smiles	O=C(NC)C1=CC=C(C2=NN3C(N=C2)=NC=C3CC4=CC=C5N=CC=CC5=C4)C=C1F.O.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	INC280 (dihydrochloride hydrate); INCB-28060 (dihydrochloride hydrate)
Available
Product Description	Capmatinib (INC280; INCB28060) dihydrochloride hydrate is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor (IC50=0.13 nM). Capmatinib dihydrochloride hydrate can inhibit phosphorylation of c-MET as well as c-MET pathway downstream effectors such as ERK1/2, AKT, FAK, GAB1, and STAT3/5. Capmatinib dihydrochloride hydrate potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis. Antitumor activity. Capmatinib dihydrochloride hydrate is largely metabolized by CYP3A4 and aldehyde oxidase[1][2][3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture and light)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	503.36
Clinical_Information	Launched
Manufacturers Research_Area	Cancer
Solubility	DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O : 3.33 mg/mL (ultrasonic)
Pathway	Apoptosis; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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