Hcyb1

Item no.	HY-132993-10mg
Manufacturer	MedChem Express
Amount	10 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	98.24
Formula	C24H20N4O
Citations	[1]Li Liu, et al. The neuroprotective and antidepressant-like effects of Hcyb1, a novel selective PDE2 inhibitor. CNS Neurosci Ther. 2018 Jul;24(7):652-660.<br>[2]Meng-Jia Zhu, et al. Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior. Psychopharmacology (Berl). 2020 Nov;237(11):3215-3224.
Smiles	O=C1NC(CC2=CC=CC=C2)=NC3=C1N=CN3C(C)C4=C5C=CC=CC5=CC=C4
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Available
Product Description	Hcyb1 is a highly selective, orally active PDE2 inhibitor. Hcyb1 has a highly selective inhibition of PDE2A (IC50=0.57 μM) and over 250-fold selectivity against other recombinant PDE family members. Hcyb1 produces neuroprotective and antidepressant‐like effects most likely mediated by cAMP/cGMP-CREB-BDNF signaling[1].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neuromodulation
MolecularWeight	380.44
Clinical_Information	No Development Reported
Manufacturers Research_Area	Neurological Disease
Solubility	DMSO : 62.5 mg/mL (ultrasonic)
Manufacturers Target	Phosphodiesterase (PDE)
Isoform	PDE2
Pathway	Metabolic Enzyme/Protease
Manufacturers Product type	Reference compound

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