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Sunvozertinib

Sunvozertinib

Item no.	HY-132842-10mg
Manufacturer	MedChem Express
CASRN	2370013-12-8
Amount	10 mg
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.92
Formula	C29H35ClFN7O3
Citations	[1]Zhengtao LI, et al. Erbb/btk inhibitors. WO2019149164A1.
Smiles	C=CC(NC1=C(N2C[C@@H](CC2)N(C)C)C=C(C(NC3=NC=CC(NC4=C(C=C(C(Cl)=C4)F)C(C)(O)C)=N3)=C1)OC)=O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	DZD9008
Available
Product Description	Sunvozertinib (DZD9008) is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor. Sunvozertinib shows IC50s of 20.4, 20.4, 1.1, 7.5, and 80.4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52)[1].
StorageTemperature	-20°C, 3 years (Powder)
Shipping	Blue Ice
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	584.08
Clinical Information	Phase 3
Manufacturers Research Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)
Target	Btk; EGFR
Manufacturers Target	Btk; EGFR
Isoform	EGFR/ErbB1/HER1; ErbB2/HER2
Manufacturers Pathway	JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Manufacturers Product type	Reference compound

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